fampridine

Ligand id: 2416

Name: fampridine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 38.91
Molecular weight 94.05
XLogP 0.37
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Fedida D, Wible B, Wang Z, Fermini B, Faust F, Nattel S, Brown AM. (1993)
Identity of a novel delayed rectifier current from human heart with a cloned K+ channel current.
Circ. Res.73 (1): 210-6. [PMID:8508531]
2. Finol-Urdaneta RK, Strüver N, Terlau H. (2006)
Molecular and Functional Differences between Heart mKv1.7 Channel Isoforms.
J. Gen. Physiol.128 (1): 133-45. [PMID:16801386]
3. Gordon E, Cohen JL, Engel R, Abbott GW. (2006)
1,4-Diazabicyclo[2.2.2]octane derivatives: a novel class of voltage-gated potassium channel blockers.
Mol. Pharmacol.69 (3): 718-26. [PMID:16317109]
4. Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. (1994)
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Mol. Pharmacol.45 (6): 1227-34. [PMID:7517498]
5. Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF. (2002)
Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain.
Proc. Natl. Acad. Sci. U.S.A.99 (2): 1035-40. [PMID:11805342]
6. Isbrandt D, Leicher T, Waldschütz R, Zhu X, Luhmann U, Michel U, Sauter K, Pongs O. (2000)
Gene structures and expression profiles of three human KCND (Kv4) potassium channels mediating A-type currents I(TO) and I(SA).
Genomics64 (2): 144-54. [PMID:10729221]
7. Juvin V, Penna A, Chemin J, Lin YL, Rassendren FA. (2007)
Pharmacological characterization and molecular determinants of the activation of transient receptor potential V2 channel orthologs by 2-aminoethoxydiphenyl borate.
Mol. Pharmacol.72 (5): 1258-68. [PMID:17673572]
8. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG. (1998)
Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
J. Biol. Chem.273 (10): 5851-7. [PMID:9488722]
9. Kirsch GE, Drewe JA. (1993)
Gating-dependent mechanism of 4-aminopyridine block in two related potassium channels.
J. Gen. Physiol.102 (5): 797-816. [PMID:8301258]
10. Korenke AR, Rivey MP, Allington DR. (2008)
Sustained-release fampridine for symptomatic treatment of multiple sclerosis.
Ann Pharmacother42 (10): 1458-65. [PMID:18780812]
11. Krapivinsky G, Medina I, Eng L, Krapivinsky L, Yang Y, Clapham DE. (1998)
A novel inward rectifier K+ channel with unique pore properties.
Neuron20 (5): 995-1005. [PMID:9620703]
12. Lang R, Lee G, Liu W, Tian S, Rafi H, Orias M, Segal AS, Desir GV. (2000)
KCNA10: a novel ion channel functionally related to both voltage-gated potassium and CNG cation channels.
Am. J. Physiol. Renal Physiol.278 (6): F1013-21. [PMID:10836990]
13. Lien CC, Martina M, Schultz JH, Ehmke H, Jonas P. (2002)
Gating, modulation and subunit composition of voltage-gated K(+) channels in dendritic inhibitory interneurones of rat hippocampus.
J. Physiol. (Lond.)538 (Pt 2): 405-19. [PMID:11790809]
14. Schmalz F, Kinsella J, Koh SD, Vogalis F, Schneider A, Flynn ER, Kenyon JL, Horowitz B. (1998)
Molecular identification of a component of delayed rectifier current in gastrointestinal smooth muscles.
Am. J. Physiol.274 (5 Pt 1): G901-11. [PMID:9612272]
15. Solari A, Uitdehaag B, Giuliani G, Pucci E, Taus C. (2001)
Aminopyridines for symptomatic treatment in multiple sclerosis.
Cochrane Database Syst Rev,  (4): CD001330. [PMID:11687106]
16. Stühmer W, Ruppersberg JP, Schröter KH, Sakmann B, Stocker M, Giese KP, Perschke A, Baumann A, Pongs O. (1989)
Molecular basis of functional diversity of voltage-gated potassium channels in mammalian brain.
EMBO J.8 (11): 3235-44. [PMID:2555158]
17. Vega-Saenz de Miera E, Moreno H, Fruhling D, Kentros C, Rudy B. (1992)
Cloning of ShIII (Shaw-like) cDNAs encoding a novel high-voltage-activating, TEA-sensitive, type-A K+ channel.
Proc. Biol. Sci.248 (1321): 9-18. [PMID:1381835]
18. Yeung SY, Ohya S, Sergeant GP, Pucovský V, Greenwood IA. (2006)
Pharmacological and molecular evidence for the involvement of Kv4.3 in ultra-fast activating K+ currents in murine portal vein myocytes.
Br. J. Pharmacol.149 (6): 676-86. [PMID:17016508]