capsaicin

Ligand id: 2486

Name: capsaicin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 58.56
Molecular weight 305.2
XLogP 4.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Topically applied capsaicin is used to relieve muscle or joint pain by causing a sensation of heat and with regular use causes a reduction in the pain messenger substance P.
Mechanism Of Action and Pharmacodynamic Effects
Capsaicin selectively binds to the TRPV1 channel that resides on the membranes of pain and heat-sensing neurons and causes these channels to open at a temperature below normal channel operation. This gives rise ot the sensation of heat. Prolonged activation of these neurons by capsaicin depletes presynaptic substance P and the neuons become unable to signal pain for an extended period of time.