capsaicin

Ligand id: 2486

Name: capsaicin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 58.56
Molecular weight 305.2
XLogP 4.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV1 Activator Agonist 7.5 pEC50 - 5
pEC50 7.5 (EC50 3.16x10-8 M) [5]
Voltage: -100.0 – 160.0 mV
CFTR Activator Potentiation - - -
Selectivity at mouse ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
TRPV1 Activator Agonist 8.0 pEC50 - 2
pEC50 8.0 [2]
Voltage: Physiological
Kv1.7 Channel blocker - 4.6 pIC50 - 4
pIC50 4.6 [4]
Kv1.1 Channel blocker - 4.5 pIC50 - 3
pIC50 4.5 [3]
Kv3.1 Channel blocker - 3.8 pIC50 - 3
pIC50 3.8 [3]
Selectivity at rat ion channels
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
Kv1.2 Channel blocker Pore blocker 4.4 pKd - 3
pKd 4.4 (Kd 4.5x10-5 M) [3]
TRPV1 Activator Agonist 6.1 pEC50 - 1
pEC50 6.1 [1]
Voltage: -40.0 mV