capsaicin

Ligand id: 2486

Name: capsaicin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 58.56
Molecular weight 305.2
XLogP 4.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Kv1.2 Rn Channel blocker Pore blocker 4.4 pKd - 3
pKd 4.4 (Kd 4.5x10-5 M) [3]
TRPV1 Mm Activator Agonist 8.0 pEC50 - 2
pEC50 8.0 [2]
Voltage: Physiological
TRPV1 Hs Activator Agonist 7.5 pEC50 - 5
pEC50 7.5 (EC50 3.16x10-8 M) [5]
Voltage: -100.0 – 160.0 mV
TRPV1 Rn Activator Agonist 6.1 pEC50 - 1
pEC50 6.1 [1]
Voltage: -40.0 mV
Kv1.7 Mm Channel blocker - 4.6 pIC50 - 4
pIC50 4.6 [4]
Kv1.1 Mm Channel blocker - 4.5 pIC50 - 3
pIC50 4.5 [3]
Kv3.1 Mm Channel blocker - 3.8 pIC50 - 3
pIC50 3.8 [3]
CFTR Hs Activator Potentiation - - -