capsaicin

Ligand id: 2486

Name: capsaicin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 58.56
Molecular weight 305.2
XLogP 4.23
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. (1997)
The capsaicin receptor: a heat-activated ion channel in the pain pathway.
Nature389 (6653): 816-24. [PMID:9349813]
2. Correll CC, Phelps PT, Anthes JC, Umland S, Greenfeder S. (2004)
Cloning and pharmacological characterization of mouse TRPV1.
Neurosci. Lett.370 (1): 55-60. [PMID:15489017]
3. Grissmer S, Nguyen AN, Aiyar J, Hanson DC, Mather RJ, Gutman GA, Karmilowicz MJ, Auperin DD, Chandy KG. (1994)
Pharmacological characterization of five cloned voltage-gated K+ channels, types Kv1.1, 1.2, 1.3, 1.5, and 3.1, stably expressed in mammalian cell lines.
Mol. Pharmacol.45 (6): 1227-34. [PMID:7517498]
4. Kalman K, Nguyen A, Tseng-Crank J, Dukes ID, Chandy G, Hustad CM, Copeland NG, Jenkins NA, Mohrenweiser H, Brandriff B, Cahalan M, Gutman GA, Chandy KG. (1998)
Genomic organization, chromosomal localization, tissue distribution, and biophysical characterization of a novel mammalian Shaker-related voltage-gated potassium channel, Kv1.7.
J. Biol. Chem.273 (10): 5851-7. [PMID:9488722]
5. Voets T, Droogmans G, Wissenbach U, Janssens A, Flockerzi V, Nilius B. (2004)
The principle of temperature-dependent gating in cold- and heat-sensitive TRP channels.
Nature430 (7001): 748-54. [PMID:15306801]