T4

Ligand id: 2635

Name: T4

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 5
Topological polar surface area 92.78
Molecular weight 776.69
XLogP 2.85
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the treatment of hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma and stupor either alone or in combination with antithyroid agents.
Mechanism Of Action and Pharmacodynamic Effects
Converted to the active metabolite triiodothyronine (T3) in the liver, which then binds to thyroid hormone binding proteins before binding to thyroid hormone receptors in the cytoplasm and nucleus.
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