Ligand id: 2648

Name: tamibarotene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 66.4
Molecular weight 351.18
XLogP 7.28
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Approved in Japan for the treatment of acute promyelocytic leukemia, tamibarotene was withdrawn in Europe for this use in 2009. ClinicalTrials.gov has several records for clinical trials involving tamibarotene- click here to access these records.
Mechanism Of Action and Pharmacodynamic Effects
Agonist for retinoic acid alpha and beta receptors.