testosterone

Ligand id: 2858

Name: testosterone

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 2
Hydrogen bond donors 1
Rotatable bonds 0
Topological polar surface area 37.3
Molecular weight 288.21
XLogP 3.64
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Uses in males include management of congenital or acquired hypogonadism, hypogonadism associated with HIV infection, and male climacteric (andopause). Used in females include palliative treatment of androgen-responsive, advanced inoperable metastasis carcinoma of the breast in women who are 1-5 years postmenopausal, and in combination with estrogens to manage vasomotor symptoms associated with the menopause in women who do not repond to estrogen treatment alone.
Mechanism Of Action and Pharmacodynamic Effects
Androgen receptor agonist. Testosterone is also converted to estradiol in thereby leading to the activation of estogen receptors.
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