gallamine

Ligand id: 356

Name: gallamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 21
Topological polar surface area 27.69
Molecular weight 510.46
XLogP 4.26
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
This drug is used to induce skeletal muscle relaxation during anesthesic and mechanical ventilation procedures. Note that there is no information regarding approval for medical use of gallamine triethiodide on the US FDA website. Individual national agencies may have granted marketing approval.
Mechanism Of Action and Pharmacodynamic Effects
Gallamine is an antagonist of muscle-type nicotinic acetylcholine receptors. The drug antagonises acetylcholine action at muscarinic acetylcholine receptors in the muscle end-plate and prevents activation of the muscle contraction process.