Ligand id: 356

Name: gallamine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 0
Hydrogen bond donors 0
Rotatable bonds 21
Topological polar surface area 27.69
Molecular weight 510.46
XLogP 4.26
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

1. Clark AL, Mitchelson F. (1976)
The inhibitory effect of gallamine on muscarinic receptors.
Br. J. Pharmacol., 58 (3): 323-31. [PMID:990587]
2. Kovacs I, Yamamura HI, Waite SL, Varga EV, Roeske WR. (1998)
Pharmacological comparison of the cloned human and rat M2 muscarinic receptor genes expressed in the murine fibroblast (B82) cell line.
J Pharmacol Exp Ther, 284: 500-507. [PMID:9454790]
3. Lazareno S, Birdsall NJM. (1995)
Detection, quantitation and verification of allosteric interactions of agents with labelled and unlabelled ligands at G protein-coupled receptors, interactions of strychnine and acetylcholine at muscarinic receptors.
Mol. Pharmacol., 48: 362-378. [PMID:7651370]
4. Tränkle C, Weyand O, Voigtländer U, Mynett A, Lazareno S, Birdsall NJ, Mohr K. (2003)
Interactions of orthosteric and allosteric ligands with [3H]dimethyl-W84 at the common allosteric site of muscarinic M2 receptors.
Mol Pharmacol, 64: 180-190. [PMID:12815174]