Ligand id: 4789

Name: 5-fluorouracil

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 0
Topological polar surface area 58.2
Molecular weight 130.02
XLogP -0.59
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Fluorouracil may be used topically to treat actinic or solar keratoses and certain superficial basal cell carcinomas. Fluorouracil is given by injection as palliative therapy for various cancers of the digestive system.
Mechanism Of Action and Pharmacodynamic Effects
5-fluorouracil intereferes with DNA and RNA synthesis. The primary effect is on DNA synthesis, where the fluoroacil mimics normal pyrimidines, and prevents their incorporation into DNA during the S phase of the cell cycle, thus initiating cell death.