miglitol

Ligand id: 4842

Name: miglitol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 5
Rotatable bonds 3
Topological polar surface area 104.39
Molecular weight 207.11
XLogP -2.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to improve glycemic control in type 2 diabetes patients.
Mechanism Of Action and Pharmacodynamic Effects
Miglitol inhibits membrane-bound intestinal alpha-glucoside hydrolase enzymes. These enzymes have the function of hydrolysing oligosaccharides and disaccharides to glucose and other monosaccharides. therefore their inhibition leads to delayed glucose absorption and lowering of postprandial hyperglycemia.