Ligand id: 4842

Name: miglitol

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 5
Rotatable bonds 3
Topological polar surface area 104.39
Molecular weight 207.11
XLogP -2.26
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

1. Jones K, Sim L, Mohan S, Kumarasamy J, Liu H, Avery S, Naim HY, Quezada-Calvillo R, Nichols BL, Pinto BM et al.. (2011)
Mapping the intestinal alpha-glucogenic enzyme specificities of starch digesting maltase-glucoamylase and sucrase-isomaltase.
Bioorg. Med. Chem., 19 (13): 3929-34. [PMID:21669536]
2. Kuriyama C, Kamiyama O, Ikeda K, Sanae F, Kato A, Adachi I, Imahori T, Takahata H, Okamoto T, Asano N. (2008)
In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures.
Bioorg. Med. Chem., 16 (15): 7330-6. [PMID:18595718]
3. Mohan S, Sim L, Rose DR, Pinto BM. (2010)
Probing the active-site requirements of human intestinal N-terminal maltase-glucoamylase: Synthesis and enzyme inhibitory activities of a six-membered ring nitrogen analogue of kotalanol and its de-O-sulfonated derivative.
Bioorg. Med. Chem., 18 (22): 7794-8. [PMID:20970346]
4. Voss AA, Díez-Sampedro A, Hirayama BA, Loo DD, Wright EM. (2007)
Imino sugars are potent agonists of the human glucose sensor SGLT3.
Mol. Pharmacol., 71 (2): 628-34. [PMID:17110502]