Ligand id: 6388

Name: rivaroxaban

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View more information in the IUPHAR Pharmacology Education Project: rivaroxaban

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 1
Rotatable bonds 6
Topological polar surface area 116.42
Molecular weight 435.07
XLogP 1.87
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Factor Xa inhibitor for the prevention of venous thromboembolic events.
Click here to link to ClinicalTrials.gov's listing of Phase III trials evaluating rivaroxaban for efficacy in additional indications.
Mechanism Of Action and Pharmacodynamic Effects
Competitive inhibitor of free and clot bound factor Xa, which blocks the amplification of the coagulation cascade, preventing thrombus formation. This family of drugs inhibits coagulation without using antithrombin as a mediator.
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