Ligand id: 6836

Name: pegaptanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 13
Hydrogen bond donors 4
Rotatable bonds 27
Topological polar surface area 180.56
Molecular weight 541.28
XLogP 0.58
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat neovascular (wet) age-related macular degeneration
Mechanism Of Action and Pharmacodynamic Effects
A pegylated anti-VEGF nucleic acid aptamer which inhibits angiogenesis and blood vessel permeability when administered intraoccularly (into the vitreous humor)
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