Ligand id: 6836

Name: pegaptanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 13
Hydrogen bond donors 4
Rotatable bonds 27
Topological polar surface area 180.56
Molecular weight 541.28
XLogP 0.58
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

1. Gragoudas ES, Adamis AP, Cunningham Jr ET, Feinsod M, Guyer DR, VEGF Inhibition Study in Ocular Neovascularization Clinical Trial Group. (2004)
Pegaptanib for neovascular age-related macular degeneration.
N. Engl. J. Med., 351 (27): 2805-16. [PMID:15625332]
2. Nimjee SM, Rusconi CP, Sullenger BA. (2005)
Aptamers: an emerging class of therapeutics.
Annu. Rev. Med., 56: 555-83. [PMID:15660527]