repaglinide

Ligand id: 6841

Name: repaglinide

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 5
Hydrogen bond donors 2
Rotatable bonds 11
Topological polar surface area 78.87
Molecular weight 452.27
XLogP 6.09
No. Lipinski's rules broken 2

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used to treat diabetes mellitus type 2, often as adjunct to diet and exercise, to improve glycemic control
Mechanism Of Action and Pharmacodynamic Effects
A meglitinide class drug, a short-acting insulin secretagogue. Action is dependent on the presence functioning β cells and glucose. Repaglinide increases insulin release by inhibiting ATP-sensitive potassium channels in a glucose-dependent manner.
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