ribavirin

Ligand id: 6842

Name: ribavirin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 9
Hydrogen bond donors 4
Rotatable bonds 3
Topological polar surface area 143.72
Molecular weight 244.08
XLogP -3.04
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A nucleoside antimetabolite antiviral agent blocking nucleic acid synthesis used against several RNA and DNA viruses. Used orally (alongside interferon drugs) to treat hepatitis C and in an aerosol form to treat respiratory syncytial virus-related diseases in children.
Mechanism Of Action and Pharmacodynamic Effects
Diverse effects lead to a significant reduction of intracellular guanosine triphosphate pools and inhibition of viral RNA and protein synthesis, in addition to lethal mutagenisis following ribavirin incorporation into the viral genome.
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