nepafenac

Ligand id: 7564

Name: nepafenac

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 86.18
Molecular weight 254.11
XLogP 3.16
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Nepafenac is indicated for the treatment of pain and inflammation associated with cataract surgery [2].
Mechanism Of Action and Pharmacodynamic Effects
As with other NSAIDs, this drug reduces prostaglandin synthesis by inhibiting cyclooxegenase (COX) activity [6]. Note that the active metabolite is amfenac.
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