nepafenac

Ligand id: 7564

Name: nepafenac

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 4
Topological polar surface area 86.18
Molecular weight 254.11
XLogP 3.16
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Gamache DA, Graff G, Brady MT, Spellman JM, Yanni JM. (2000)
Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: I. Assessment of anti-inflammatory efficacy.
Inflammation24 (4): 357-70. [PMID:10850857]
2. Jones BM, Neville MW. (2013)
Nepafenac: an ophthalmic nonsteroidal antiinflammatory drug for pain after cataract surgery.
Ann Pharmacother47 (6): 892-6. [PMID:23715071]
3. Ke TL, Graff G, Spellman JM, Yanni JM. (2000)
Nepafenac, a unique nonsteroidal prodrug with potential utility in the treatment of trauma-induced ocular inflammation: II. In vitro bioactivation and permeation of external ocular barriers.
Inflammation24 (4): 371-84. [PMID:10850858]
4. Lane SS. (2006)
Nepafenac: a unique nonsteroidal prodrug.
Int Ophthalmol Clin46 (4): 13-20. [PMID:17060788]
5. Takahashi K, Saishin Y, Saishin Y, Mori K, Ando A, Yamamoto S, Oshima Y, Nambu H, Melia MB, Bingaman DP et al.. (2003)
Topical nepafenac inhibits ocular neovascularization.
Invest. Ophthalmol. Vis. Sci.44 (1): 409-15. [PMID:12506103]
6. Zanetti FR, Fulco EA, Chaves FR, da Costa Pinto AP, Arieta CE, Lira RP. (2012)
Effect of preoperative use of topical prednisolone acetate, ketorolac tromethamine, nepafenac and placebo, on the maintenance of intraoperative mydriasis during cataract surgery: a randomized trial.
Indian J Ophthalmol60 (4): 277-81. [PMID:22824596]