Ligand id: 7619

Name: enclomiphene

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 1
Hydrogen bond donors 0
Rotatable bonds 9
Topological polar surface area 12.47
Molecular weight 405.19
XLogP 9.85
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Enclomiphene is under investigation as a treatment for men of reproductive age with low testosterone due to secondary hypogonadism [2-3]. ClinicalTrials.gov hosts a list of all currently registered trials assessing this potential drug (as Androxal® aka enclomiphene citrate).
Enclomiphene is an active component of the approved drug clomiphene. See the ligand page for enclomiphene for details of its clinical use and mechanism of action.
Mechanism Of Action and Pharmacodynamic Effects
Enclomiphene is an oral therapy designed to treat the inadequate pituitary hormone levels which cause secondary hypogonadism. This provides a more convenient way of taking this treatment, as opposed to traditional testosterone replacement therapy which is administered by injection or in gels.

See the ligand page for clomiphene for details of its mechanism of action.