cis-JB253

Ligand id: 7787

Name: cis-JB253

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 8
Hydrogen bond donors 2
Rotatable bonds 10
Topological polar surface area 111.61
Molecular weight 457.21
XLogP 6.81
No. Lipinski's rules broken 1

Molecular properties generated using the CDK

No information available.
Mechanism Of Action and Pharmacodynamic Effects
When sulfonylureas bind to ​SUR1 (the sulfonylurea receptor regulatory subunit), they act to block the ​Kir6.2 inward rectifier (the ion pore forming component of the KATP channel), leading to cell depolarization and opening of voltage-dependent Ca2+ channels [2]. This drives downstream processes that converge to increase insulin secretion [3].