pindolol

Ligand id: 91

Name: pindolol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 57.28
Molecular weight 248.15
XLogP 1.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
Used in the management of hypertension, edema, ventricular tachycardias and atrial fibrillation.
Mechanism Of Action and Pharmacodynamic Effects
Blocking of beta-1 adrenoceptors in the heart inhibits the effects of adrenaline and noradrenaline, leading to a decrease in heart rate and blood pressure. Beta-2 adrenoceptor inhibition in the juxtaglomerular apparatus results in inhibition of the production of renin, leading to inhibition in the production of angiotensin II and aldosterone production and inhibiting vasoconstriction and water retention.
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