pindolol

Ligand id: 91

Name: pindolol

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Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 3
Hydrogen bond donors 3
Rotatable bonds 6
Topological polar surface area 57.28
Molecular weight 248.15
XLogP 1.62
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Knight AR, Misra A, Quirk K, Benwell K, Revell D, Kennett G, Bickerdike M. (2004)
Pharmacological characterisation of the agonist radioligand binding site of 5-HT(2A), 5-HT(2B) and 5-HT(2C) receptors.
Naunyn Schmiedebergs Arch Pharmacol370: 114-123. [PMID:15322733]
2. Krushinski Jr JH, Schaus JM, Thompson DC, Calligaro DO, Nelson DL, Luecke SH, Wainscott DB, Wong DT. (2007)
Indoloxypropanolamine analogues as 5-HT(1A) receptor antagonists.
Bioorg. Med. Chem. Lett.17 (20): 5600-4. [PMID:17804228]
3. Newman-Tancredi A, Verriele L, Chaput C, Millan MJ. (1998)
Labelling of recombinant human and native rat serotonin 5-HT1A receptors by a novel, selective radioligand, [3H]-S 15535: definition of its binding profile using agonists, antagonists and inverse agonists.
Naunyn Schmiedebergs Arch Pharmacol357: 205-217. [PMID:9550290]