phenacemide   Click here for help

GtoPdb Ligand ID: 7265

Synonyms: Phenurone®
Approved drug
phenacemide is an approved drug (FDA (1951))
Compound class: Synthetic organic
Comment: Phenacemide is a ureide (acetylurea) anticonvulsant. It is a congener and ring-opened analogue of the hydantoin phenytoin, and is structurally related to the barbiturate family of drugs and other hydantoins. Use of phenacemide was widely discontinued due to toxic side-effects.
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 3
Rotatable bonds 3
Topological polar surface area 76.67
Molecular weight 178.07
XLogP 1.35
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES OC(=NC(=N)O)Cc1ccccc1
Isomeric SMILES OC(=NC(=N)O)Cc1ccccc1
InChI InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13)
InChI Key XPFRXWCVYUEORT-UHFFFAOYSA-N
References
1. Coker SB. (1986)
The use of phenacemide for intractable partial complex epilepsy in children.
Pediatr Neurol, 2 (4): 230-2. [PMID:3508693]
2. McPhee SJ and Hammer GD. (2009)
Pathophysiology of Disease An Introduction to Clinical Medicine.  In  Pathophysiology of Disease An Introduction to Clinical Medicine, Sixth Edition(6th Edition) (McGraw-Hill Medical) 768. [ISBN:0071621679]
3. Somjen GG. (2004)
Ions in the Brain: Normal Function, Seizures, and Stroke.  In  Ions in the Brain (Oxford University Press, Incorporated) . [ISBN:0198034598]