apelin receptor early endogenous ligand

Ligand id: 7930

Name: apelin receptor early endogenous ligand

Abbreviated name: ELA

Species: Human

References
1. Chng SC, Ho L, Tian J, Reversade B. (2013)
ELABELA: a hormone essential for heart development signals via the apelin receptor.
Dev. Cell27 (6): 672-80. [PMID:24316148]
2. Deng C, Chen H, Yang N, Feng Y, Hsueh AJ. (2015)
Apela regulates fluid homeostasis by binding to the APJ receptor to activate Gi signaling.
J. Biol. Chem.,  [Epub ahead of print]. [PMID:25995451]
3. Yang P, Read C, Kuc RE, Buonincontri G, Southwood M, Torella R, Upton PD, Crosby A, Sawiak SJ, Carpenter TA et al.. (2017)
Elabela/Toddler Is an Endogenous Agonist of the Apelin APJ Receptor in the Adult Cardiovascular System, and Exogenous Administration of the Peptide Compensates for the Downregulation of Its Expression in Pulmonary Arterial Hypertension.
Circulation135 (12): 1160-1173. [PMID:28137936]