Synonyms: (+)-Tetrandrine | (S,S)-Tetrandrine | D-Tetrandrine | Tetrandrin
tetrandrine is an approved drug (China)
Compound class:
Synthetic organic
Comment: Tetrandrine is a compound that can be extracted from the Stephania tetrandra vine, or synthesised chemically. It has been demonstrated to act as an inhibitor of multiple ion channels, including two-pore channels 1 and 2 (TPC1/2), and L- and T-type calcium channels [2-3]. The TPC calcium channels appear to be important for Ebola virus infection of host cells, and in vitro either ablation of TPC expression or tetrandrine-mediated inhibition of TPC channels reduces Ebola infection (IC50 55 nM) [3].
SARS-CoV-2 infection (COVID-19): Tetrandrine is being studied in clinical trial for potential to treat COVID-19. The biological and pharmacological rationale for this use was reviewed in [1]. |
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