ADAM33

Target id: 1673

Nomenclature: ADAM33

Family: M12: Astacin/Adamalysin

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     ADAM33 has curated GtoImmuPdb data

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 813 20p13 ADAM33 ADAM metallopeptidase domain 33
Mouse - 797 2 F1 Adam33 a disintegrin and metallopeptidase domain 33
Rat - - 3q36 Adam33 ADAM metallopeptidase domain 33
Database Links
Specialist databases
MEROPS M12.244 (Hs)
Other databases
BRENDA
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
GenitoUrinary Development Molecular Anatomy Project
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 3.4.24.-

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Affinity Units Reference
IK-862 Hs Inhibition 7.8 pKi 1
pKi 7.8 (Ki 1.5x10-8 M) [1]
INCB3619 Hs Inhibition 6.0 pIC50 1
pIC50 6.0 (IC50 1.026x10-6 M) [1]
Immunopharmacology Comments
ADAM33 is implicated in the pathology of asthma [2].
Immuno Disease Associations
Disease Name:  Asthma
Disease Synonyms:  no synonynms
Comment:  ADAM33 is implicated in the pathology of asthma.
Disease X-refs:  Disease Ontology: DOID:2841
OMIM: 600807
References:  2
Clinically-Relevant Mutations and Pathophysiology
Disease:  Asthma, susceptibility to
Disease Ontology: DOID:2841
OMIM: 600807

References

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1. Georgiadis D, Yiotakis A. (2008) Specific targeting of metzincin family members with small-molecule inhibitors: progress toward a multifarious challenge. Bioorg. Med. Chem.16 (19): 8781-94. [PMID:18790648]

2. Van Eerdewegh P, Little RD, Dupuis J, Del Mastro RG, Falls K, Simon J, Torrey D, Pandit S, McKenny J, Braunschweiger K et al.. (2002) Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature418 (6896): 426-30. [PMID:12110844]

How to cite this page

M12: Astacin/Adamalysin: ADAM33. Last modified on 16/03/2017. Accessed on 18/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1673.