cyclin dependent kinase 17

Target id: 1970

Nomenclature: cyclin dependent kinase 17

Abbreviated Name: CDK17

Family: TAIRE subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for cyclin dependent kinase 17 in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 523 12q23.1 CDK17 cyclin dependent kinase 17
Mouse - 523 10 C2 Cdk17 cyclin-dependent kinase 17
Rat - 523 7q13 Cdk17 cyclin-dependent kinase 17
Previous and Unofficial Names
PCTAIRE protein kinase 2 | PCTAIRE2 | cyclin-dependent kinase 17
Database Links
BRENDA
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction
EC Number: 2.7.11.22
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
http://www.discoverx.com/services/drug-discovery-development-services/kinase-profiling/kinomescan
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: PCTK2
Ligand Sp. Type Action Affinity Units
R547 Hs Inhibitor Inhibition 9.1 pKd
AT-7519 Hs Inhibitor Inhibition 9.0 pKd
BMS-387032 Hs Inhibitor Inhibition 7.9 pKd
AST-487 Hs Inhibitor Inhibition 7.8 pKd
staurosporine Hs Inhibitor Inhibition 7.0 pKd
foretinib Hs Inhibitor Inhibition 6.8 pKd
tamatinib Hs Inhibitor Inhibition 6.5 pKd
fedratinib Hs Inhibitor Inhibition 6.5 pKd
alvocidib Hs Inhibitor Inhibition 6.3 pKd
lestaurtinib Hs Inhibitor Inhibition 6.1 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »

References

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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

TAIRE subfamily: cyclin dependent kinase 17. Last modified on 20/03/2013. Accessed on 21/07/2018. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1970.