Interleukin-2 receptor

Target id: 2297

Nomenclature: Interleukin-2 receptor

Family: IL-2 receptor family

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

   GtoImmuPdb view: OFF :     Interleukin-2 receptor has curated GtoImmuPdb data

Quaternary Structure: Subunits
Interleukin-2 receptor subunit α (Ligand-binding subunit)
Interleukin-2 receptor subunit β (Ligand-binding subunit)
Interleukin-2 receptor subunit γ (Other subunit)

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Agonists
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Ligand Sp. Action Affinity Units Reference
IL-2 {Sp: Human} Hs Agonist - -
Antagonists
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Ligand Sp. Action Affinity Units Reference
AF12198 Hs Antagonist - - 1
[1]
Ro26-4550 Hs Antagonist - - 2
[2]
IL-1 receptor antagonist {Sp: Human} Hs Antagonist - -
Immunopharmacology Comments
The IL-2 receptor is a heterotrimeric complex of the interleukin-2 receptor subunits α, β and γ. The α and β subunits can bind IL-2, and signalling is generated by heterodimerization of the β and γ subunits.

References

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1. Akeson AL, Woods CW, Hsieh LC, Bohnke RA, Ackermann BL, Chan KY, Robinson JL, Yanofsky SD, Jacobs JW, Barrett RW et al.. (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J. Biol. Chem.271 (48): 30517-23. [PMID:8940020]

2. Tilley JW, Chen L, Fry DC, Emerson SD, Powers GD, Biondi D, Varnell T, Trilles R, Guthrie R, Mennona F, Kaplan G, LeMahieu RA, Carson M, Han RJ, Liu CM, Palermo R, Ju G. (1997) Identification of a small molecule inhibitor of the IL-2/IL-2R alpha receptor interaction which binds to IL-2. Journal of the American Chemical Society119 (32): 7589-7590.

How to cite this page

IL-2 receptor family: Interleukin-2 receptor. Last modified on 17/07/2017. Accessed on 21/10/2017. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2297.