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Interleukin-2 receptor

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Immunopharmacology Ligand target has curated data in GtoImmuPdb

Target id: 2297

Nomenclature: Interleukin-2 receptor

Family: IL-2 receptor family

Quaternary Structure: Subunits
Interleukin-2 receptor subunit α (Ligand-binding subunit)
Interleukin-2 receptor subunit β (Ligand-binding subunit)
Interleukin-2 receptor subunit γ (Other subunit)
Natural/Endogenous Ligands Click here for help
IL-2 {Sp: Human}
IL-1 receptor antagonist {Sp: Human}

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Agonists
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Ligand Sp. Action Value Parameter Reference
IL-2 {Sp: Human} Peptide Approved drug Ligand is endogenous in the given species Immunopharmacology Ligand Hs Agonist - -
Antagonists
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
AF12198 Peptide Click here for species-specific activity table Immunopharmacology Ligand Hs Antagonist - - 1
[1]
Ro26-4550 Small molecule or natural product Immunopharmacology Ligand Hs Antagonist - - 2
[2]
IL-1 receptor antagonist {Sp: Human} Peptide Click here for species-specific activity table Ligand is endogenous in the given species Immunopharmacology Ligand Hs Antagonist - -
Immunopharmacology Comments
The IL-2 receptor is a heterotrimeric complex of the interleukin-2 receptor subunits α, β and γ. The α and β subunits can bind IL-2, and signalling is generated by heterodimerization of the β and γ subunits.

References

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1. Akeson AL, Woods CW, Hsieh LC, Bohnke RA, Ackermann BL, Chan KY, Robinson JL, Yanofsky SD, Jacobs JW, Barrett RW et al.. (1996) AF12198, a novel low molecular weight antagonist, selectively binds the human type I interleukin (IL)-1 receptor and blocks in vivo responses to IL-1. J. Biol. Chem., 271 (48): 30517-23. [PMID:8940020]

2. Tilley JW, Chen L, Fry DC, Emerson SD, Powers GD, Biondi D, Varnell T, Trilles R, Guthrie R, Mennona F, Kaplan G, LeMahieu RA, Carson M, Han RJ, Liu CM, Palermo R, Ju G. (1997) Identification of a small molecule inhibitor of the IL-2/IL-2R alpha receptor interaction which binds to IL-2. J. Am. Chem. Soc., 119 (32): 7589-7590. DOI: 10.1021/ja970702x

How to cite this page

IL-2 receptor family: Interleukin-2 receptor. Last modified on 17/07/2017. Accessed on 23/11/2020. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2297.