grassystatin A [Ligand Id: 8674] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL567893 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| ADAM10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5028] [GtoPdb: 1658] [UniProtKB: O14672] | ||||||||
| ChEMBL | Inhibition of ADAM10 | B | 4 | pIC50 | >100000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of ADAM10 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ADAM17 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3706] [GtoPdb: 1662] [UniProtKB: P78536] | ||||||||
| ChEMBL | Inhibition of TACE after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of TACE | B | 5.91 | pIC50 | 1230 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ADAM9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5982] [GtoPdb: 1657] [UniProtKB: Q13443] | ||||||||
| ChEMBL | Inhibition of ADAM9 | B | 4.34 | pIC50 | 46100 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of ADAM9 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Angiotensin-converting enzyme in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1808] [GtoPdb: 1613] [UniProtKB: P12821] | ||||||||
| ChEMBL | Inhibition of ACE1 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| beta-secretase 1/Beta-secretase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4822] [GtoPdb: 2330] [UniProtKB: P56817] | ||||||||
| ChEMBL | Inhibition of BACE1 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of BACE1 by fluorescence assay | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2012) 55: 10749-10765 [PMID:23181502] |
| calpain 1/Calpain 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3891] [GtoPdb: 2336] [UniProtKB: P07384] | ||||||||
| ChEMBL | Inhibition of calpain 1 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] | ||||||||
| ChEMBL | Inhibition of caspase 1 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 10/Caspase-10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5037] [GtoPdb: 1626] [UniProtKB: Q92851] | ||||||||
| ChEMBL | Inhibition of caspase 10 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 14/Caspase-14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5991] [GtoPdb: 1627] [UniProtKB: P31944] | ||||||||
| GtoPdb | - | - | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-47 [PMID:19715320] |
| ChEMBL | Inhibition of caspase 14 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 2/Caspase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4884] [GtoPdb: 1618] [UniProtKB: P42575] | ||||||||
| ChEMBL | Inhibition of caspase 2 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574] | ||||||||
| ChEMBL | Inhibition of caspase 3 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 4/Caspase-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2226] [GtoPdb: 1620] [UniProtKB: P49662] | ||||||||
| ChEMBL | Inhibition of caspase 4 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 4/Caspase-4 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075276] [GtoPdb: 1620] [UniProtKB: P70343] | ||||||||
| ChEMBL | Inhibition of mouse caspase 11 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 5/Caspase-5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3131] [GtoPdb: 1621] [UniProtKB: P51878] | ||||||||
| ChEMBL | Inhibition of caspase 5 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 6/Caspase-6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308] [GtoPdb: 1622] [UniProtKB: P55212] | ||||||||
| ChEMBL | Inhibition of caspase 6 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 7/Caspase-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3468] [GtoPdb: 1623] [UniProtKB: P55210] | ||||||||
| ChEMBL | Inhibition of caspase 7 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 8/Caspase-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790] | ||||||||
| ChEMBL | Inhibition of caspase 8 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Caspase 9/Caspase-9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2273] [GtoPdb: 1625] [UniProtKB: P55211] | ||||||||
| ChEMBL | Inhibition of caspase 9 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin B/Cathepsin B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4072] [GtoPdb: 2343] [UniProtKB: P07858] | ||||||||
| ChEMBL | Inhibition of cathepsin B after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin D/Cathepsin D in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2581] [GtoPdb: 2345] [UniProtKB: P07339] | ||||||||
| ChEMBL | Inhibition of cathepsin D after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin D in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin D in human MCF7 cells by fluorescence assay | B | 6 | pIC50 | 1000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin D by fluorescence assay | B | 7.4 | pIC50 | 40 | nM | IC50 | J Med Chem (2012) 55: 10749-10765 [PMID:23181502] |
| ChEMBL | Inhibition of cathepsin D using MCA-KPILFFRLK(Dnp)-D-R-NH2 as substrate incubated for 10 to 15 mins prior to substrate addition measured every 5 min for 2 hrs by fluorometry | B | 7.4 | pIC50 | 40 | nM | IC50 | Bioorg Med Chem (2012) 20: 4774-4780 [PMID:22748705] |
| ChEMBL | Inhibition of cathepsin D | B | 7.58 | pIC50 | 26.5 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| GtoPdb | - | - | 7.58 | pIC50 | 26.5 | nM | IC50 | J Med Chem (2009) 52: 5732-47 [PMID:19715320] |
| ChEMBL | Inhibition of human liver cathepsin D using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 15 mins followed by substrate addition measured at 5 mins interval for 120 mins by fluorescence assay | B | 7.59 | pIC50 | 26 | nM | IC50 | J Nat Prod (2017) 80: 2969-2986 [PMID:29087712] |
| cathepsin E/Cathepsin E in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3092] [GtoPdb: 2346] [UniProtKB: P14091] | ||||||||
| ChEMBL | Inhibition of cathepsin E after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin E in human MCF7 cells by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin E in human MCF7 cells treated for 1 hr measured after washout and trypsin treatment by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of recombinant human C-terminal His10-tagged cathepsin E (Gln18 to Pro396 residues) using Mca-Gly-Lys-Pro-Ile-Leu-PhePhe-Arg-Leu-Lys-(Dnp)-D-Arg-NH2 as substrate pretreated for 15 mins followed by substrate addition measured at 5 mins interval for 120 mins by fluorescence assay | B | 9.05 | pIC50 | 0.9 | nM | IC50 | J Nat Prod (2017) 80: 2969-2986 [PMID:29087712] |
| GtoPdb | - | - | 9.05 | pIC50 | 0.89 | nM | IC50 | J Med Chem (2009) 52: 5732-47 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin E | B | 9.05 | pIC50 | 0.89 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin E by fluorescence assay | B | 9.1 | pIC50 | 0.8 | nM | IC50 | J Med Chem (2012) 55: 10749-10765 [PMID:23181502] |
| ChEMBL | Inhibition of cathepsin E using MCA-KPILFFRLK(Dnp)-D-R-NH2 as substrate incubated for 10 to 15 mins prior to substrate addition measured every 5 min for 2 hrs by fluorometry | B | 9.1 | pIC50 | 0.8 | nM | IC50 | Bioorg Med Chem (2012) 20: 4774-4780 [PMID:22748705] |
| cathepsin H/Cathepsin H in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2225] [GtoPdb: 2349] [UniProtKB: P09668] | ||||||||
| ChEMBL | Inhibition of cathepsin H after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin K/Cathepsin K in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL268] [GtoPdb: 2350] [UniProtKB: P43235] | ||||||||
| ChEMBL | Inhibition of cathepsin K after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| ChEMBL | Inhibition of cathepsin X after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin V/Cathepsin L2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3272] [GtoPdb: 2352] [UniProtKB: O60911] | ||||||||
| ChEMBL | Inhibition of cathepsin V after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin S/Cathepsin S in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2954] [GtoPdb: 2353] [UniProtKB: P25774] | ||||||||
| ChEMBL | Inhibition of cathepsin S after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin Z/Cathepsin Z in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4160] [GtoPdb: 2354] [UniProtKB: Q9UBR2] | ||||||||
| ChEMBL | Inhibition of cathepsin Z after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| chymase 1/Chymase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4068] [GtoPdb: 2340] [UniProtKB: P23946] | ||||||||
| ChEMBL | Inhibition of chymase after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| coagulation factor X/Coagulation factor X in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL244] [GtoPdb: 2359] [UniProtKB: P00742] | ||||||||
| ChEMBL | Inhibition of factor 10a after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| coagulation factor XI/Coagulation factor XI in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2820] [GtoPdb: 2360] [UniProtKB: P03951] | ||||||||
| ChEMBL | Inhibition of factor 11a after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| cathepsin C/Dipeptidyl peptidase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2252] [GtoPdb: 2344] [UniProtKB: P53634] | ||||||||
| ChEMBL | Inhibition of cathepsin C after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487] | ||||||||
| ChEMBL | Inhibition of DPP4 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| dipeptidyl peptidase 9/Dipeptidyl peptidase IX in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4793] [GtoPdb: 2357] [UniProtKB: Q86TI2] | ||||||||
| ChEMBL | Inhibition of DPP9 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| dipeptidyl peptidase 8/Dipeptidyl peptidase VIII in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4657] [GtoPdb: 2356] [UniProtKB: Q6V1X1] | ||||||||
| ChEMBL | Inhibition of DPP8 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Elastase 1 in Pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3517] [UniProtKB: P00772] | ||||||||
| ChEMBL | Inhibition of porcine pancreatic elastase after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| kallikrein related peptidase 4/Kallikrein 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4446] [GtoPdb: 2374] [UniProtKB: Q9Y5K2] | ||||||||
| ChEMBL | Inhibition of kallikrein 4 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| kallikrein related peptidase 5/Kallikrein 5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4447] [GtoPdb: 2375] [UniProtKB: Q9Y337] | ||||||||
| ChEMBL | Inhibition of kallikrein 5 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| kallikrein related peptidase 8/Kallikrein 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4812] [GtoPdb: 2378] [UniProtKB: O60259] | ||||||||
| ChEMBL | Inhibition of kallikrein 8 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP1/Matrix metalloproteinase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL332] [GtoPdb: 1628] [UniProtKB: P03956] | ||||||||
| ChEMBL | Inhibition of MMP1 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP10/Matrix metalloproteinase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4270] [GtoPdb: 1634] [UniProtKB: P09238] | ||||||||
| ChEMBL | Inhibition of MMP10 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP11/Matrix metalloproteinase 11 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2867] [GtoPdb: 1635] [UniProtKB: P24347] | ||||||||
| ChEMBL | Inhibition of MMP11 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP12/Matrix metalloproteinase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4393] [GtoPdb: 1636] [UniProtKB: P39900] | ||||||||
| ChEMBL | Inhibition of MMP12 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP13/Matrix metalloproteinase 13 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL280] [GtoPdb: 1637] [UniProtKB: P45452] | ||||||||
| ChEMBL | Inhibition of MMP13 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP14/Matrix metalloproteinase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3869] [GtoPdb: 1638] [UniProtKB: P50281] | ||||||||
| ChEMBL | Inhibition of MMP14 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP2/Matrix metalloproteinase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL333] [GtoPdb: 1629] [UniProtKB: P08253] | ||||||||
| ChEMBL | Inhibition of MMP2 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP3/Matrix metalloproteinase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL283] [GtoPdb: 1630] [UniProtKB: P08254] | ||||||||
| ChEMBL | Inhibition of MMP3 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP7/Matrix metalloproteinase 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4073] [GtoPdb: 1631] [UniProtKB: P09237] | ||||||||
| ChEMBL | Inhibition of MMP7 after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP8/Matrix metalloproteinase 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4588] [GtoPdb: 1632] [UniProtKB: P22894] | ||||||||
| ChEMBL | Inhibition of MMP8 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| MMP9/Matrix metalloproteinase 9 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL321] [GtoPdb: 1633] [UniProtKB: P14780] | ||||||||
| ChEMBL | Inhibition of MMP9 catalytic domain after 10 to 15 mins by fluorescence assay | B | 5.3 | pIC50 | 5000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Papain in Carica papaya (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4779] [UniProtKB: P00784] | ||||||||
| ChEMBL | Inhibition of papaya papain after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| kallikrein B1/Plasma kallikrein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2000] [GtoPdb: 2379] [UniProtKB: P03952] | ||||||||
| ChEMBL | Inhibition of plasma kallikrein after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| plasminogen/Plasminogen in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1801] [GtoPdb: 2394] [UniProtKB: P00747] | ||||||||
| ChEMBL | Inhibition of human plasmin after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| renin/Renin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL286] [GtoPdb: 2413] [UniProtKB: P00797] | ||||||||
| ChEMBL | Inhibition of human renin after 10 to 15 mins by fluorescence assay | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| coagulation factor II, thrombin/Thrombin in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL204] [GtoPdb: 2362] [UniProtKB: P00734] | ||||||||
| ChEMBL | Inhibition of thrombin alpha after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| Trypsin I in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3769] [UniProtKB: P00760] | ||||||||
| ChEMBL | Inhibition of bovine pancreatic trypsin after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| tryptase alpha/beta 1/Tryptase beta-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2617] [GtoPdb: 2424] [UniProtKB: Q15661] | ||||||||
| ChEMBL | Inhibition of tryptase beta2 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| tryptase gamma 1/Tryptase gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4955] [GtoPdb: 2425] [UniProtKB: Q9NRR2] | ||||||||
| ChEMBL | Inhibition of human lung tryptase gamma1 after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| plasminogen activator, urokinase/Urokinase-type plasminogen activator in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3286] [GtoPdb: 2393] [UniProtKB: P00749] | ||||||||
| ChEMBL | Inhibition of urokinase after 10 to 15 mins by fluorescence assay | B | 5 | pIC50 | 10000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
| protein C, inactivator of coagulation factors Va and VIIIa/Vitamin K-dependent protein C in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4444] [GtoPdb: 2396] [UniProtKB: P04070] | ||||||||
| ChEMBL | Inhibition of activated protein C after 10 to 15 mins by fluorescence assay in presence of 50% glycine | B | 4.3 | pIC50 | 50000 | nM | IC50 | J Med Chem (2009) 52: 5732-5747 [PMID:19715320] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
