nimodipine

Ligand id: 2523

Name: nimodipine

IUPHAR Pharmacology Education Project (PEP) logo

View more information in the IUPHAR Pharmacology Education Project: nimodipine

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 10
Topological polar surface area 117
Molecular weight 418.17
XLogP 4.6
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from GtoPdb and ChEMBL (where available) across species

Selectivity at ion channels
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Cav1.2 Rn Gating inhibitor Antagonist 6.8 pIC50 - 4
pIC50 6.8 [4]
Voltage: -80.0 mV
Cav1.3 Rn Gating inhibitor Antagonist 5.7 – 6.6 pIC50 - 2,4
pIC50 5.7 – 6.6 [2,4]
Voltage: -80.0 – -40.0 mV
Cav1.1 Hs Gating inhibitor Antagonist ~6.0 pIC50 -
pIC50 ~6.0 (IC50 ~1x10-6 M)
Voltage: -70.0 mV
Cav1.4 Hs Gating inhibitor Antagonist ~6.0 pIC50 -
pIC50 ~6.0 (IC50 ~1x10-6 M)
Voltage: -70.0 mV
CFTR Hs Activator Potentiation - - -
Selectivity at nuclear hormone receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Affinity Units Concentration range (M) Reference
Mineralocorticoid receptor Hs Antagonist Antagonist 6.8 pIC50 - 1
pIC50 6.8 (IC50 1.6x10-7 M) inhibition of aldosterone-induced luciferase activity in a reporter system driven by the mineralocorticoid receptor ligand binding domain [1]
Targets where the ligand is described in the comment field
Target Comment