pertuzumab   Click here for help

GtoPdb Ligand ID: 5046

Synonyms: 2C4 | Omnitarg® (obsolete trade name) | Perjeta®
Approved drug
pertuzumab is an approved drug (FDA (2012), EMA (2013))
Compound class: Antibody
Comment: Annotated peptide sequences for this antibody are available in its IMGT/mAB-DB record.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
Selectivity at catalytic receptors
Key to terms and symbols Click column headers to sort
Target Sp. Type Action Value Parameter Concentration range (M) Reference
erb-b2 receptor tyrosine kinase 2 Primary target of this compound Hs Antibody Inhibition >8.0 pIC50 - 5
⤷ pIC50 >8.0 (IC50 <1x10-8 M) [5]
Description: Preferred value for inhibition of heregulin β1 binding to MCF7 cells.
Ligand mentioned in the following text fields
Type I RTKs: ErbB (epidermal growth factor) receptor family comments