crenolanib

Ligand id: 7882

Name: crenolanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 78.43
Molecular weight 443.23
XLogP 3.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

View interactive charts of activity data from ChEMBL and GtoPdb across species (New!)

Selectivity at human catalytic receptors
Key to terms and symbols Click column headers to sort
Target Type Action Affinity Units Concentration range (M) Reference
fms related tyrosine kinase 3 Inhibitor Inhibition 9.1 pKd - 1
pKd 9.1 (Kd 7.4x10-10 M) [1]
platelet derived growth factor receptor alpha Inhibitor Inhibition 8.7 pKd - 1
pKd 8.7 (Kd 2.1x10-9 M) [1]
platelet derived growth factor receptor beta Inhibitor Inhibition 8.5 pKd - 1
pKd 8.5 (Kd 3.2x10-9 M) [1]
colony stimulating factor 1 receptor Inhibitor Inhibition 7.5 pKd - 1
pKd 7.5 (Kd 3x10-8 M) [1]
KIT proto-oncogene receptor tyrosine kinase Inhibitor Inhibition 7.1 pKd - 1
pKd 7.1 (Kd 7.8x10-8 M) [1]