crenolanib

Ligand id: 7882

Name: crenolanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 78.43
Molecular weight 443.23
XLogP 3.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

No information available.
Summary of Clinical Use
A Phase II clinical study for relapsed/refractory acute myeloid leukemia with FLT3 activating mutations (NCT01657682) has been completed. Phase 3 studies in FLT3 mutation positive AML (NCT02298166) and PDGFRA mutation positive gastrointestinal stromal tumours (NCT02847429) are underway (May 2017). Click here to link to ClinicalTrials.gov's complete listing of crenolanib trials.