crenolanib

Ligand id: 7882

Name: crenolanib

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 6
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 78.43
Molecular weight 443.23
XLogP 3.93
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

Classification
Compound class Synthetic organic
IUPAC Name
1-[2-[5-[(3-methyloxetan-3-yl)methoxy]benzimidazol-1-yl]quinolin-8-yl]piperidin-4-amine
International Nonproprietary Names
INN number INN
9459 crenolanib
Synonyms
ARO-002 | CP 868596 | CP-868596
Database Links
CAS Registry No. 670220-88-9
ChEMBL Ligand CHEMBL2105728
GtoPdb PubChem SID 223366211
PubChem CID 10366136
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Wikipedia Crenolanib
Comments
Crenolanib is an orally bioavailable benzamidazole that selectively and potently inhibits signaling of wild-type and mutant isoforms of class the III receptor tyrosine kinases FLT3 (FMS-like yyrosine kinase 3), PDGFRα (platelet-derived growth factor receptor), and PDGFRβ [1], preferentially binding to phosphorylated active kinases with the ‘DFG in’ conformation.