enoxacin

Ligand id: 8882

Name: enoxacin

Structure and Physico-chemical Properties

2D Structure
Calculated Physico-chemical Properties
Hydrogen bond acceptors 7
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 85.77
Molecular weight 320.13
XLogP 0.75
No. Lipinski's rules broken 0

Molecular properties generated using the CDK

References
1. Emde A, Eitan C, Liou LL, Libby RT, Rivkin N, Magen I, Reichenstein I, Oppenheim H, Eilam R, Silvestroni A et al.. (2015)
Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.
EMBO J.,  [Epub ahead of print]. [PMID:26330466]
2. Ostrov DA, Magis AT, Wronski TJ, Chan EK, Toro EJ, Donatelli RE, Sajek K, Haroun IN, Nagib MI, Piedrahita A et al.. (2009)
Identification of enoxacin as an inhibitor of osteoclast formation and bone resorption by structure-based virtual screening.
J. Med. Chem.52 (16): 5144-51. [PMID:19630402]
3. Qin A, Cheng TS, Pavlos NJ, Lin Z, Dai KR, Zheng MH. (2012)
V-ATPases in osteoclasts: structure, function and potential inhibitors of bone resorption.
Int. J. Biochem. Cell Biol.44 (9): 1422-35. [PMID:22652318]
4. Valdez G, Heyer MP, Feng G, Sanes JR. (2014)
The role of muscle microRNAs in repairing the neuromuscular junction.
PLoS ONE9 (3): e93140. [PMID:24664281]