myosin IIIA | NinaC subfamily | IUPHAR/BPS Guide to PHARMACOLOGY

myosin IIIA

Target id: 2112

Nomenclature: myosin IIIA

Abbreviated Name: MYO3A

Family: NinaC subfamily

Annotation status:  image of an orange circle Annotated and awaiting review. Please contact us if you can help with reviewing.  » Email us

   GtoImmuPdb view: OFF :     Currently no data for myosin IIIA in GtoImmuPdb

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 1616 10p11.1 MYO3A myosin IIIA
Mouse - 1621 2 A3 Myo3a myosin IIIA
Rat - 1620 17q12.3 Myo3a myosin IIIA
Previous and Unofficial Names
Database Links
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
DiscoveRx KINOMEscan® screen
A screen of 72 inhibitors against 456 human kinases. Quantitative data were derived using DiscoveRx KINOMEscan® platform.
Reference: 1-2

Key to terms and symbols Click column headers to sort
Target used in screen: MYO3A
Ligand Sp. Type Action Affinity Units
AST-487 Hs Inhibitor Inhibition 7.4 pKd
NVP-TAE684 Hs Inhibitor Inhibition 7.2 pKd
lestaurtinib Hs Inhibitor Inhibition 6.6 pKd
staurosporine Hs Inhibitor Inhibition 6.3 pKd
KW-2449 Hs Inhibitor Inhibition 6.1 pKd
PP-242 Hs Inhibitor Inhibition 6.1 pKd
SU-14813 Hs Inhibitor Inhibition 5.8 pKd
axitinib Hs Inhibitor Inhibition 5.7 pKd
foretinib Hs Inhibitor Inhibition 5.6 pKd
SB203580 Hs Inhibitor Inhibition <5.5 pKd
Displaying the top 10 most potent ligands  View all ligands in screen »
Clinically-Relevant Mutations and Pathophysiology
Disease:  Deafness, autosomal recessive 30; DFNB30
Synonyms: Autosomal recessive nonsyndromic deafness [Disease Ontology: DOID:0050565]
Autosomal recessive non-syndromic sensorineural deafness type DFNB [Orphanet: ORPHA90636]
Disease Ontology: DOID:0050565
OMIM: 607101
Orphanet: ORPHA90636


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1. Davis MI, Hunt JP, Herrgard S, Ciceri P, Wodicka LM, Pallares G, Hocker M, Treiber DK, Zarrinkar PP. (2011) Comprehensive analysis of kinase inhibitor selectivity. Nat. Biotechnol., 29 (11): 1046-51. [PMID:22037378]

2. Wodicka LM, Ciceri P, Davis MI, Hunt JP, Floyd M, Salerno S, Hua XH, Ford JM, Armstrong RC, Zarrinkar PP et al.. (2010) Activation state-dependent binding of small molecule kinase inhibitors: structural insights from biochemistry. Chem. Biol., 17 (11): 1241-9. [PMID:21095574]

How to cite this page

NinaC subfamily: myosin IIIA. Last modified on 18/08/2014. Accessed on 19/11/2018. IUPHAR/BPS Guide to PHARMACOLOGY,