Akt (Protein kinase B)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

« Hide More detailed introduction

The action of phosphatidylinositol 3-kinase (PI3K), a downstream kinase activated by receptor tyrosine kinases, produces a series of phosphorylated phosphoinositides, which recruit 3-phosphoinositide-dependent kinase (PDPK1, O15530) activity to the plasma membrane, leading to activation of Akt. Akt may be activated by PIP3, PDK1-mediated phosphorylation [1] and mTORC2-mediated phosphorylation [3-4].

Enzymes

Akt1 (v-akt murine thymoma viral oncogene homolog 1) Show summary » More detailed page

Akt2 (v-akt murine thymoma viral oncogene homolog 2) Show summary » More detailed page

AKT3 (v-akt murine thymoma viral oncogene homolog 3) Show summary » More detailed page

References

Show »

How to cite this family page

Database page citation:

Akt (Protein kinase B). Accessed on 01/10/2014. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=285.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Spedding M, Peters JA and Harmar AJ, CGTP Collaborators. (2013) The Concise Guide to PHARMACOLOGY 2013/14: Enzymes. Br J Pharmacol. 170: 1797–1867.