Akt (Protein kinase B)

Unless otherwise stated all data on this page refer to the human proteins. Gene information is provided for human (Hs), mouse (Mm) and rat (Rn).

Overview

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The action of phosphatidylinositol 3-kinase (PI3K), a downstream kinase activated by receptor tyrosine kinases, produces a series of phosphorylated phosphoinositides, which recruit 3-phosphoinositide-dependent kinase (PDPK1, O15530) activity to the plasma membrane, leading to activation of Akt. Akt may be activated by PIP3, PDK1-mediated phosphorylation [1] and mTORC2-mediated phosphorylation [6,11].

Enzymes

Akt1 (v-akt murine thymoma viral oncogene homolog 1) Show summary » More detailed page

Akt2 (v-akt murine thymoma viral oncogene homolog 2) Show summary » More detailed page

AKT3 (v-akt murine thymoma viral oncogene homolog 3) Show summary » More detailed page

References

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How to cite this family page

Database page citation:

Akt (Protein kinase B). Accessed on 27/06/2016. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/FamilyDisplayForward?familyId=285.

Concise Guide to PHARMACOLOGY citation:

Alexander SPH, Fabbro D, Kelly E, Marrion N, Peters JA, Benson HE, Faccenda E, Pawson AJ, Sharman JL, Southan C, Davies JA and CGTP Collaborators (2015) The Concise Guide to PHARMACOLOGY 2015/16: Enzymes. Br J Pharmacol. 172: 6024-6109.