Cav1.3
|
|
|
N/A |
Channel blocker |
Antagonist |
- |
- |
2x10-4 |
16 |
|
⤷ |
Conc range: 2x10-4 M
[16]
Voltage:
-60.0 mV
|
TRPP1
|
|
|
Hs |
Channel blocker |
- |
- |
- |
1x10-4 |
15 |
|
⤷ |
Conc range: 1x10-4 M
[15]
Voltage:
0.0 mV
|
TRPA1
|
|
|
Hs |
Activator |
Activation |
5.8 |
pEC50 |
- |
1,13 |
|
⤷ |
pEC50
5.8
(EC50 1.4x10-6 M)
[1,13]
Description: Sodium and calcium imaging
Conditions: CHO cells expressing human TRPA1 and mouse dorsal root ganglion neurons
|
TRPA1
|
|
|
Mm |
Activator |
Activation |
5.7 |
pEC50 |
- |
1,13 |
|
⤷ |
pEC50
5.7
(EC50 2.1x10-6 M)
[1,13]
|
Cav2.1
|
|
|
Oc |
Channel blocker |
- |
6.0 – 6.3 |
pIC50 |
- |
|
|
⤷ |
pIC50
6.0 – 6.3
Voltage:
-80.0 – -60.0 mV
|
Cav2.3
|
|
|
Hs |
Channel blocker |
Antagonist |
6.1 |
pIC50 |
- |
18 |
|
⤷ |
pIC50
6.1
[18]
Voltage:
-90.0 mV
|
Cav1.2
|
|
|
Oc |
Channel blocker |
- |
5.7 – 6.0 |
pIC50 |
- |
7 |
|
⤷ |
pIC50
5.7 – 6.0
[7]
Voltage:
-80.0 mV
|
Hv1
|
|
|
Hs |
Channel blocker |
- |
~5.0 |
pIC50 |
- |
|
|
⤷ |
pIC50
~5.0
(IC50 ~1x10-5 M)
|
Cav1.1
|
|
|
Rn |
Channel blocker |
Antagonist |
4.3 |
pIC50 |
- |
2 |
|
⤷ |
pIC50
4.3
[2]
Voltage:
-80.0 mV
|
ClC-4
|
|
|
Hs |
Channel blocker |
- |
4.2 |
pIC50 |
- |
14 |
|
⤷ |
pIC50
4.2
(IC50 6.8x10-5 M)
[14]
|
Navi2.1
|
|
|
Hs |
Channel blocker |
- |
3.8 |
pIC50 |
- |
|
|
⤷ |
pIC50
3.8
(IC50 1.5x10-4 M)
|
TPC1
|
|
|
Hs |
Channel blocker |
Inhibition |
3.7 |
pIC50 |
- |
3 |
|
⤷ |
pIC50
3.7
(IC50 1.8x10-4 M)
[3]
|
CatSper1
|
|
|
Mm |
Channel blocker |
Inhibition |
3.7 |
pIC50 |
- |
10 |
|
⤷ |
pIC50
3.7
(IC50 2x10-4 M)
[10]
Description: Whole cell patch clamp
|
CatSper2
|
|
|
Mm |
Channel blocker |
Inhibition |
3.7 |
pIC50 |
- |
9 |
|
⤷ |
pIC50
3.7
(IC50 2x10-4 M)
[9]
Description: Whole cell patch clamp.
|
CatSper3
|
|
|
Mm |
Channel blocker |
Antagonist |
3.7 |
pIC50 |
- |
10 |
|
⤷ |
pIC50
3.7
(IC50 2x10-4 M)
[10]
Description: Whole cell patch clamp electrophysiology.
|
CatSper4
|
|
|
Mm |
Channel blocker |
Antagonist |
3.7 |
pIC50 |
- |
10 |
|
⤷ |
pIC50
3.7
(IC50 2x10-4 M)
[10]
Description: Whole cell patch clamp electrophysiology.
|
TRPC6
|
|
|
Mm |
Channel blocker |
Antagonist |
3.6 |
pIC50 |
- |
8 |
|
⤷ |
pIC50
3.6
(IC50 2.53x10-4 M)
[8]
Voltage:
-60.0 mV
|
Nav1.7
|
|
|
Hs |
Channel blocker |
Pore blocker |
3.0 |
pIC50 |
- |
11 |
|
⤷ |
pIC50
3.0
[11]
Voltage:
-100.0 mV
|
ASIC2
|
|
|
Hs |
Channel blocker |
- |
~3.0 |
pIC50 |
- |
17 |
|
⤷ |
pIC50
~3.0
(IC50 ~1x10-3 M)
Partial inhibition
[17]
|
TRPV6
|
|
|
Hs |
Channel blocker |
- |
- |
- |
- |
|
|
⤷ |
|
Kv12.1
|
|
|
Mm |
Gating inhibitor |
- |
- |
- |
- |
19 |
|
⤷ |
[19]
Description: 1 mM Cd2+ slows activation 5-fold and shifts V0.5 for activation by +35 mV
Conditions: Heterologous expression in Xenopus oocytes
|
ClC-1
|
|
|
Hs |
Channel blocker |
- |
- |
- |
- |
|
|
⤷ |
|
ClC-2
|
|
|
Hs |
Channel blocker |
- |
- |
- |
- |
|
|
⤷ |
|