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This section gives an overview of the disease, and where available shows the following:
More information can be found in the help pages.
✖Disease ID: | 1023 | |
Name: | Fatty liver disease, nonalcoholic, susceptibility to, 1; NAFLD1 | |
Associated with: | 2 targets |
Database Links |
OMIM:
613282 |
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖NLRP6 | |
Role: | NLRP6 negatively regulates the progression of non-alcoholic fatty liver disease and mtabolic syndrome via modulation of gut bacteria. |
References: | 1 |
regulator of G-protein signaling 16 | |
References: | 2 |
Click ligand name to view ligand summary page
Click the arrow in the final column to expand comments
More information can be found in the help pages.
✖No ligand related data available for Fatty liver disease, nonalcoholic, susceptibility to, 1; NAFLD1
1. Henao-Mejia J, Elinav E, Jin C, Hao L, Mehal WZ, Strowig T, Thaiss CA, Kau AL, Eisenbarth SC, Jurczak MJ et al.. (2012) Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity. Nature, 482 (7384): 179-85. [PMID:22297845]
2. Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC et al.. (2011) Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner. J Biol Chem, 286 (17): 15116-25. [PMID:21357625]