Atrial Fibrillation
GtoPdb Disease Summaries
This section gives an overview of the disease, and where available shows the following:
- Synonyms: Shows known synonyms for the disease.
- Description: Gives a basic description/definition of the disease.
- Database Link: External links to the same disease at the Disease Ontology, OMIM or Orphanet sites.
- Immunopharmacology comments: General comments about the target's role in immunopharmacology, provided by GtoImmuPdb curators.
- Associated with: Counts are displayed for the total targets the disease is associated with in GtoPdb. The counts of targets and ligands of immunological relevance associated to the disease are also shown.
More information can be found in the help pages.
✖| Disease ID: | 1180 | |
| Name: | Atrial Fibrillation | |
| Associated with: | 2 targets | |
Targets
GtoPdb Disease Summaries - Targets
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖| KCa2.2 | |
| Drugs: | NS8593 and UCL1684 have demonstrated efficacy in protecting against or terminating atrial fibrillation both ex vivo and in vivo in rats, dogs, pigs and horses. |
| Side effects: | Tremor, ataxia and convulsions at higher NS8593 doses. |
| Therapeutic use: | Negative KCa2 channel gating modulators have been proposed for the treatment of atrial fibrillation. |
| References: | 2,4,7 |
| KCa2.3 | |
| Comments: |
Common variants in KCNN3 are associated with lone atrial fibrillation. Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. Significant association of rs13376333 in KCNN3 on chromosome 1q21 with atrial fibrillation in a Taiwanese population. Regulation of the SK3 channel by microRNA-499--potential role in atrial fibrillation. Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation KCNN3 SNP rs13376333 on Chromosome 1q21 Confers Increased Risk of Atrial Fibrillation. |
| References: | 1,3,5-6,8-9 |
Ligands
GtoPdb Disease Summaries - Ligands
Click ligand name to view ligand summary page
- Approved: If the ligand is an approved drug this is indicated, along with approval bodies.
- Immuno: Immuno icon indicates the ligand is immuno-relevant
Click the arrow in the final column to expand comments
- Immuno Disease Comments: Curatorial comments specifically added as part of GtoImmuPdb. They give more information on the association between the ligand and disease in the context of immunopharmacology.
- Clinical Use: General clinical comments relating to the ligand and may not necessarily be specific to the disease in question. With hyperlink to more details on the ligand summary pages.
- Bioactivty Comments: Curatorial comments specifically about the compounds biological activity - with hyperlink to more details on the ligand summary pages.
More information can be found in the help pages.
✖No ligand related data available for Atrial Fibrillation
References
1. Chang SH, Chang SN, Hwang JJ, Chiang FT, Tseng CD, Lee JK, Lai LP, Lin JL, Wu CK, Tsai CT. (2012) Significant association of rs13376333 in KCNN3 on chromosome 1q21 with atrial fibrillation in a Taiwanese population. Circ J, 76 (1): 184-8. [PMID:22019810]
2. Diness JG, Skibsbye L, Jespersen T, Bartels ED, Sørensen US, Hansen RS, Grunnet M. (2011) Effects on atrial fibrillation in aged hypertensive rats by Ca(2+)-activated K(+) channel inhibition. Hypertension, 57 (6): 1129-35. [PMID:21502564]
3. Ellinor PT, Lunetta KL, Glazer NL, Pfeufer A, Alonso A, Chung MK, Sinner MF, de Bakker PI, Mueller M, Lubitz SA et al.. (2010) Common variants in KCNN3 are associated with lone atrial fibrillation. Nat Genet, 42 (3): 240-4. [PMID:20173747]
4. Haugaard MM, Hesselkilde EZ, Pehrson S, Carstensen H, Flethøj M, Præstegaard KF, Sørensen US, Diness JG, Grunnet M, Buhl R et al.. (2015) Pharmacologic inhibition of small-conductance calcium-activated potassium (SK) channels by NS8593 reveals atrial antiarrhythmic potential in horses. Heart Rhythm, 12 (4): 825-35. [PMID:25542425]
5. Li C, Wang F, Yang Y, Fu F, Xu C, Shi L, Li S, Xia Y, Wu G, Cheng X et al.. (2011) Significant association of SNP rs2106261 in the ZFHX3 gene with atrial fibrillation in a Chinese Han GeneID population. Hum Genet, 129 (3): 239-46. [PMID:21107608]
6. Ling TY, Wang XL, Chai Q, Lau TW, Koestler CM, Park SJ, Daly RC, Greason KL, Jen J, Wu LQ et al.. (2013) Regulation of the SK3 channel by microRNA-499--potential role in atrial fibrillation. Heart Rhythm, 10 (7): 1001-9. [PMID:23499625]
7. Qi XY, Diness JG, Brundel BJ, Zhou XB, Naud P, Wu CT, Huang H, Harada M, Aflaki M, Dobrev D et al.. (2014) Role of small-conductance calcium-activated potassium channels in atrial electrophysiology and fibrillation in the dog. Circulation, 129 (4): 430-40. [PMID:24190961]
8. Tsai CT, Hsieh CS, Chang SN, Chuang EY, Juang JM, Lin LY, Lai LP, Hwang JJ, Chiang FT, Lin JL. (2015) Next-generation sequencing of nine atrial fibrillation candidate genes identified novel de novo mutations in patients with extreme trait of atrial fibrillation. J Med Genet, 52 (1): 28-36. [PMID:25391453]
9. Yao JL, Zhou YF, Yang XJ, Qian XD, Jiang WP. (2015) KCNN3 SNP rs13376333 on Chromosome 1q21 Confers Increased Risk of Atrial Fibrillation. Int Heart J, 56 (5): 511-5. [PMID:26370375]
