Top ▲
This section gives an overview of the disease, and where available shows the following:
More information can be found in the help pages.
✖Disease ID: | 125 | |
Name: | Nail disorder, nonsyndromic congenital, 10; NDNC10 | |
Associated with: | 1 target |
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖FZD6 | |
References: | 1 |
Mutations: | FZD6 is associated with 3 mutation. Click here for details ![]() |
Click ligand name to view ligand summary page
Click the arrow in the final column to expand comments
More information can be found in the help pages.
✖No ligand related data available for Nail disorder, nonsyndromic congenital, 10; NDNC10
1. Fröjmark AS, Schuster J, Sobol M, Entesarian M, Kilander MB, Gabrikova D, Nawaz S, Baig SM, Schulte G, Klar J et al.. (2011) Mutations in frizzled 6 cause isolated autosomal-recessive nail dysplasia. Am J Hum Genet, 88 (6): 852-60. [PMID:21665003]
2. Naz G, Pasternack SM, Perrin C, Mattheisen M, Refke M, Khan S, Gul A, Simons M, Ahmad W, Betz RC. (2012) FZD6 encoding the Wnt receptor frizzled 6 is mutated in autosomal-recessive nail dysplasia. Br J Dermatol, 166 (5): 1088-94. [PMID:22211385]
3. Raza SI, Muhammad N, Khan S, Ahmad W. (2013) A novel missense mutation in the gene FZD6 underlies autosomal recessive nail dysplasia. Br J Dermatol, 168 (2): 422-5. [PMID:22861124]