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Acute pancreatitis

Disease ID:1261
Name:Acute pancreatitis
Associated with:0 target
1 immuno-relevant ligand
Description
A sudden inflammation of the pancreas that is commonly caused by gallstones or alcohol abuse.

Targets

No target related data available for Acute pancreatitis

Ligands

Key to terms and symbols Click ligand name to view ligand summary Click column headers to sort
Ligand References Clinical and Disease comments
CM4620
Immuno Disease Comments: Phase 2 clinical candidate for the treatment of acute pancreatitis- see NCT03401190
Bioactivity Comments: Preclinical results indicate that inhibition of Orai1 reduces calcium-induced injury to human and mouse pancreatic acinar cells in vitro, and to whole pancreas in mouse models [1]. | View biological activity

References

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1. Wen L, Voronina S, Javed MA, Awais M, Szatmary P, Latawiec D, Chvanov M, Collier D, Huang W, Barrett J et al.. (2015) Inhibitors of ORAI1 Prevent Cytosolic Calcium-Associated Injury of Human Pancreatic Acinar Cells and Acute Pancreatitis in 3 Mouse Models. Gastroenterology, 149 (2): 481-92.e7. [PMID:25917787]