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myocarditis

Disease ID:1291
Name:myocarditis
Associated with:1 target
Description
Myocarditis can be caused by a number of mechanisms, including viral infection, drug reaction or a general inflammatory condition.

Targets

TIM3 (CD366)
Role:  A case of recurrent autoinflammatory, early onset febrile myocarditis has been linked to a homozygous mutation in the gene for TIM3. The mutation causes TIM3 deficiency, and disruption of the TIM3 inhibitory checkpoint, which ultimately lead to excessive IL-1β production and defective regulation of T cell proliferation/activation.
Drugs:  Anakinra
Comments:  In this patient clinical symptoms responded to IL-1 receptor antagonist anakinra.
References:  1

Ligands

No ligand related data available for myocarditis

References

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1. Pernaa N, Vakkuri A, Arvonen M, Kuismin O, Santaniemi W, Glumoff V, Lappi-Blanco E, Lantto U, Okkonen M, Kaikkonen K et al.. (2024) Germline HAVCR2/TIM-3 Checkpoint Inhibitor Receptor Deficiency in Recurrent Autoinflammatory Myocarditis. J Clin Immunol, 44 (3): 81. [PMID:38485795]