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Cardiac arrhythmia

Disease ID:177
Name:Cardiac arrhythmia
Associated with:2 targets


Role:  Supraventricular tachycardias caused by re-entrant circuits.
Drugs:  Adenosine (activation of Kir3.1/3.4 via purinergic receptors).
Side effects:  Flushing, rapid heart rate, nausea.
Therapeutic use:  To restore normal sinus rhythm.
References:  1
Drugs:  Verapamil, methoxyverapamil, diltiazem
References:  2-3


No ligand related data available for Cardiac arrhythmia


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1. Armstrong A, Clapham DE. (2007) Pharmacology of Cardiac Rhythm. In Principles of pharmacology: the pathophysiologic basis of drug therapy (2nd edition). Edited by Dolan DE, Tashjian AH, Armstrong EJ, Armstrong AW (Lipponcott Williams and Wilkins) 307-324. [ISBN:0781783550]

2. Patten M, Maas R, Bauer P, Lüderitz B, Sonntag F, Dluzniewski M, Hatala R, Opolski G, Müller HW, Meinertz T. (2004) Suppression of paroxysmal atrial tachyarrhythmias--results of the SOPAT trial. Eur. Heart J., 25 (16): 1395-404. [PMID:15321697]

3. Poole-Wilson PA, Lubsen J, Kirwan BA, van Dalen FJ, Wagener G, Danchin N, Just H, Fox KA, Pocock SJ, Clayton TC, Motro M, Parker JD, Bourassa MG, Dart AM, Hildebrandt P, Hjalmarson A, Kragten JA, Molhoek GP, Otterstad JE, Seabra-Gomes R, Soler-Soler J, Weber S. (2004) Effect of long-acting nifedipine on mortality and cardiovascular morbidity in patients with stable angina requiring treatment (ACTION trial): randomised controlled trial. Lancet, 364 (9437): 849-57. [PMID:15351192]