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Heart failure

Disease ID:411
Name:Heart failure
Associated with:1 target


Role:  Elevated aldosterone and Cav3.2 levels associated.
Drugs:  Efonidipine
Side effects:  No serious side effects reported.
Therapeutic use:  Antihypertensive.
References:  1-3


No ligand related data available for Heart failure


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1. Lalevée N, Rebsamen MC, Barrère-Lemaire S, Perrier E, Nargeot J, Bénitah JP, Rossier MF. (2005) Aldosterone increases T-type calcium channel expression and in vitro beating frequency in neonatal rat cardiomyocytes. Cardiovasc Res, 67 (2): 216-24. [PMID:15919070]

2. Okayama S, Imagawa K, Naya N, Iwama H, Somekawa S, Kawata H, Horii M, Nakajima T, Uemura S, Saito Y. (2006) Blocking T-type Ca2+ channels with efonidipine decreased plasma aldosterone concentration in healthy volunteers. Hypertens Res, 29 (7): 493-7. [PMID:17044661]

3. Shimizu M, Ogawa K, Sasaki H, Uehara Y, Otsuka Y, Okumura H, Kusaka M, Hasuda T, Yamada T, Mochizuki S. (2003) Effects of efonidipine, an L- and T-Type dual calcium channel blocker, on heart rate and blood pressure in patients with mild to severe hypertension: an uncontrolled, open-label pilot study. Curr Ther Res Clin Exp, 64 (9): 707-14. [PMID:24944418]