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Interstitial cystitis

Disease ID:506
Name:Interstitial cystitis
Associated with:2 targets
1 immuno-relevant target
1 immuno-relevant ligand
Database Links
Disease Ontology: DOID:13949


References:  1
Comments:  Phase 3 evaluating the SHIP1 activator rosiptor is underway (see NCT02858453).
Ligand interactions: 
Ligand Comments
Phase 3 study for interstitial cystitis/bladder pain syndrome is ongoing (see NCT02858453).


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Ligand References Clinical and Disease comments
Immuno Disease Comments: Phase 3 study for interstitial cystitis/bladder pain syndrome is ongoing (see NCT02858453).
Clinical Use: AQX-1125 has reached Phase 2 clinical trial in chronic inflammatory conditions such as unstable chronic obstructive pulmonary disease (COPD) and atopic dermatitis, and Phase 3 for interstitial cystitis/bladder pain syndrome [2] (see NCT02858453). Click here to link to's full list of AQX-1125 trials. | View clinical data
Bioactivity Comments: AQX-1125 activates INPP5D enzyme activity by 20% (reducing the KM from 214 (control) to 180 [3]. This reduction in KM is concentration-dependent, but the compound has no effect on the enzyme's turnover constant (kcat) or maximum velocity (Vmax), which is indicative of allosteric modulation [3]. | View biological activity


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1. Keay SK, Szekely Z, Conrads TP, Veenstra TD, Barchi Jr JJ, Zhang CO, Koch KR, Michejda CJ. (2004) An antiproliferative factor from interstitial cystitis patients is a frizzled 8 protein-related sialoglycopeptide. Proc Natl Acad Sci USA, 101 (32): 11803-8. [PMID:15282374]

2. Nickel JC, Egerdie B, Davis E, Evans R, Mackenzie L, Shrewsbury SB. (2016) A Phase II Study of the Efficacy and Safety of the Novel Oral SHIP1 Activator AQX-1125 in Subjects with Moderate to Severe Interstitial Cystitis/Bladder Pain Syndrome. J Urol, 196 (3): 747-54. [PMID:26968644]

3. Stenton GR, Mackenzie LF, Tam P, Cross JL, Harwig C, Raymond J, Toews J, Wu J, Ogden N, MacRury T et al.. (2013) Characterization of AQX-1125, a small-molecule SHIP1 activator: Part 1. Effects on inflammatory cell activation and chemotaxis in vitro and pharmacokinetic characterization in vivo. Br J Pharmacol, 168 (6): 1506-18. [PMID:23121445]