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This section gives an overview of the disease, and where available shows the following:
More information can be found in the help pages.
✖Disease ID: | 513 | |
Name: | Ischemia-reperfusion injury | |
Associated with: | 1 target |
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖C5a1 receptor | |
Role: | The role of C5aR has been well studied in ischaemia/reperfusion (IR) injury. C5aR has been demonstrated to play a proinflammatory role, contributing to pathology, in IR injury of the heart, kidney, liver, intestine, and brain. |
References: | 1-9 |
Click ligand name to view ligand summary page
Click the arrow in the final column to expand comments
More information can be found in the help pages.
✖No ligand related data available for Ischemia-reperfusion injury
1. Arumugam TV, Shiels IA, Strachan AJ, Abbenante G, Fairlie DP, Taylor SM. (2003) A small molecule C5a receptor antagonist protects kidneys from ischemia/reperfusion injury in rats. Kidney Int, 63 (1): 134-42. [PMID:12472776]
2. Arumugam TV, Woodruff TM, Lathia JD, Selvaraj PK, Mattson MP, Taylor SM. (2009) Neuroprotection in stroke by complement inhibition and immunoglobulin therapy. Neuroscience, 158 (3): 1074-89. [PMID:18691639]
3. Arumugam TV, Woodruff TM, Stocks SZ, Proctor LM, Pollitt S, Shiels IA, Reid RC, Fairlie DP, Taylor SM. (2004) Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. J Hepatol, 40 (6): 934-41. [PMID:15158333]
4. de Vries B, Köhl J, Leclercq WK, Wolfs TG, van Bijnen AA, Heeringa P, Buurman WA. (2003) Complement factor C5a mediates renal ischemia-reperfusion injury independent from neutrophils. J Immunol, 170 (7): 3883-9. [PMID:12646657]
5. Fleming SD, Mastellos D, Karpel-Massler G, Shea-Donohue T, Lambris JD, Tsokos GC. (2003) C5a causes limited, polymorphonuclear cell-independent, mesenteric ischemia/reperfusion-induced injury. Clin Immunol, 108 (3): 263-73. [PMID:14499250]
6. Lewis AG, Köhl G, Ma Q, Devarajan P, Köhl J. (2008) Pharmacological targeting of C5a receptors during organ preservation improves kidney graft survival. Clin Exp Immunol, 153 (1): 117-26. [PMID:18505432]
7. Van Beek J, Bernaudin M, Petit E, Gasque P, Nouvelot A, MacKenzie ET, Fontaine M. (2000) Expression of receptors for complement anaphylatoxins C3a and C5a following permanent focal cerebral ischemia in the mouse. Exp Neurol, 161 (1): 373-82. [PMID:10683302]
8. Xu DZ, Zaets SB, Chen R, Lu Q, Rajan H, Yang X, Zhang J, Feketova E, Bogdan N, Deitch EA et al.. (2009) Elimination of C5aR prevents intestinal mucosal damage and attenuates neutrophil infiltration in local and remote organs. Shock, 31 (5): 493-9. [PMID:18791492]
9. Zhang H, Qin G, Liang G, Li J, Barrington RA, Liu DX. (2007) C5aR-mediated myocardial ischemia/reperfusion injury. Biochem Biophys Res Commun, 357 (2): 446-52. [PMID:17416341]