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This section gives an overview of the disease, and where available shows the following:
More information can be found in the help pages.
✖Disease ID: | 599 | |
Name: | Medulloblastoma | |
Associated with: | 2 targets |
Click on the target name to link to its detailed view page
Where available, information is display on the role of the target in the disease; drugs which target the disease and their therapeutic use and side-effects.
If there is mutation data curated in GtoPdb this is indicated, with a link back to the appropriate section on the target detailed view page
Immuno ligand interactions - If available, a table of immuno-relevant ligands is shown. These ligands have been curated as having an association to the disease and possess interaction data with the target in GtoPdb. The approval status of the ligand is shown, along with curator comments and an indication of whether the target is considered the primary target of the ligand.
More information can be found in the help pages.
✖FZD8 | |
References: | 2 |
Kv10.2 | |
Role: | EAG2 upregulation in a subset of medulloblastoma |
Comments: | EAG2 promotes medulloblastoma cell proliferation and migration. Knockdown of EAG2 or inhibition of EAG2 channels with channel blockers reduce medulloblastoma growth and metastasis in mouse models. |
References: | 1 |
Click ligand name to view ligand summary page
Click the arrow in the final column to expand comments
More information can be found in the help pages.
✖No ligand related data available for Medulloblastoma
1. Huang X, He Y, Dubuc AM, Hashizume R, Zhang W, Reimand J, Yang H, Wang TA, Stehbens SJ, Younger S et al.. (2015) EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. Nat Neurosci, 18 (9): 1236-46. [PMID:26258683]
2. Salsano E, Paterra R, Figus M, Menghi F, Maderna E, Pollo B, Solero CL, Massimi L, Finocchiaro G. (2012) Expression profile of frizzled receptors in human medulloblastomas. J Neurooncol, 106 (2): 271-80. [PMID:21850537]